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MOTS-c — Research overview

MOTS-c is a mitochondrial-derived peptide studied for AMPK activation, insulin sensitivity, and metabolic regulation in cellular research.

MOTS-c (Mitochondrial-Derived Peptide)

16-amino-acid peptide encoded within the mitochondrial 12S rRNA

Studied in cellular metabolism and energy-homeostasis research

Investigated for roles in metabolic-stress and insulin-sensitivity models

Often referenced in exercise-mimetic research

Acts as a signaling peptide between mitochondria and the nucleus

Research Use Notes

Supplied as lyophilized powder

Requires reconstitution before use

Research Water required for mixing (sold separately)

Swirl gently, never shake

Storage

Store lyophilized vial frozen for long-term holding

Keep reconstituted solution at 2 to 8°C

Stable refrigerated for up to 28 days

Handling

Maintain sterile workflow during reconstitution

For laboratory research use only

Compound Information

Molecular profile

What is MOTS-c（Do Not Order — Currently Under Testing）?

Type
Mitochondrial-derived peptide
CAS Number
1627580-64-6
Molecular Weight
2,174.6 g/mol
Amino Acids
16

Storage requirements

Stability Information

Avoid freeze/thaw cyclesProtect from lightKeep refrigerated
Lyophilized (powder)-20°C24+ months
Reconstituted2-8°C~30 days

Sources & References

Cell Metabolism

MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

2015 · DOI: 10.1016/j.cmet.2015.02.009 · Lee C, Cohen P, et al.

View source Nature Communications

MOTS-c Is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline

2021 · DOI: 10.1038/s41467-020-20790-0 · Reynolds JC, et al.

View source PubMed Central

MOTS-c in Metabolic Regulation and Mitochondrial Function — Review

Review

View source PubChem

MOTS-c Compound Information

View source ClinicalTrials.gov

MOTS-c Clinical Research Registry

View source

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